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dshipin">短視頻</a> <a href="http://www.z3x9u9.com/yaopin/" class="fll cell zdao">用藥指導(dǎo)</a> </div> </div> <div id="ey1uvbiufh" class="header-sub-wrap-mask" on="tap:header-sub-wrap.toggle"></div> </mip-toggle>   <div id="ey1uvbiufh" class="posr"> <div id="ey1uvbiufh" class="yilian_box_prev"></div> <div class="ey1uvbiufh" id="5G2B4Z9E" class="yilian_box"></div> </div> <div id="ey1uvbiufh" class="bw pl30 pr30 pb30 mb20"> <h1 class="f46 lh58 wbwr pt30 mb30">多發(fā)性骨髓瘤會(huì)導(dǎo)致高血壓?jiǎn)?/h1> <div id="ey1uvbiufh" class="fc9 f24 flex aic lh32 mb10"> <time class="icon-time">2025-05-24</time> <span id="ey1uvbiufh" class="icon-eye ml40"> 2860人瀏覽</span> </div> <div id="ey1uvbiufh" class="detail-content wbwr f32 lh52 pt20 taj"><p>多發(fā)性骨髓瘤可能引發(fā)繼發(fā)性高血壓，主要與腫瘤相關(guān)腎損傷、高鈣血癥、血液黏稠度增加、淀粉樣變性及治療藥物等因素有關(guān)。</p><p><img class="up_image_20111121" src="https://file.bohe.cn/fhfile1/M00/76/84/ooYBAGgwSMyAPNBnAAFGit7ixUU027.jpg"></p><p>1、腎損傷：</p><p>多發(fā)性骨髓瘤產(chǎn)生的異常免疫球蛋白可沉積于腎臟，導(dǎo)致腎功能不全。腎臟血流調(diào)節(jié)異常會(huì)激活腎素-血管緊張素系統(tǒng)，進(jìn)而引起血壓升高。需通過(guò)水化治療、控制蛋白尿等措施保護(hù)腎功能。</p><p>2、高鈣血癥：</p><p>骨髓瘤細(xì)胞破壞骨組織釋放大量鈣離子，血鈣水平升高可導(dǎo)致血管平滑肌收縮增強(qiáng)及腎臟濃縮功能受損。降鈣治療包括雙膦酸鹽類藥物、充分補(bǔ)液等，同時(shí)需監(jiān)測(cè)電解質(zhì)平衡。</p><p>3、血液高黏滯：</p><p><img class="up_image_20111121" src="https://file.bohe.cn/fhfile1/M00/76/84/ooYBAGgwSMyAE7RrAACzWNd6394908.jpg"></p><p>異常免疫球蛋白增多使血液黏稠度增高，外周血管阻力上升。血漿置換可快速降低球蛋白水平，長(zhǎng)期需通過(guò)化療控制原發(fā)病。</p><p>4、淀粉樣變性：</p><p>輕鏈蛋白在血管壁沉積引發(fā)血管硬化，血管彈性下降導(dǎo)致血壓調(diào)節(jié)障礙。靶向治療如蛋白酶體抑制劑可減少異常蛋白產(chǎn)生。</p><p>5、藥物因素：</p><p>化療藥物如沙利度胺、地塞米松等可能通過(guò)水鈉潴留或血管收縮作用影響血壓。需在醫(yī)生指導(dǎo)下調(diào)整用藥方案，必要時(shí)聯(lián)合降壓藥物。</p><p>多發(fā)性骨髓瘤患者應(yīng)每日監(jiān)測(cè)血壓并記錄波動(dòng)情況，限制鈉鹽攝入至每日5克以下，優(yōu)先選擇低脂高纖維飲食如燕麥、芹菜等。適度進(jìn)行散步、太極等低強(qiáng)度運(yùn)動(dòng)，避免劇烈活動(dòng)加重骨骼負(fù)擔(dān)。若出現(xiàn)持續(xù)頭痛、視物模糊等高血壓急癥表現(xiàn)，需立即就醫(yī)處理。定期復(fù)查腎功能、電解質(zhì)及心臟超聲，綜合評(píng)估靶器官損害程度。</p></div> <div id="ey1uvbiufh" class="f24 fc9 lh40 ta-j">免責(zé)聲明：本頁(yè)面信息為第三方發(fā)布或內(nèi)容轉(zhuǎn)載，僅出于信息傳遞目的，其作者觀點(diǎn)、內(nèi)容描述及原創(chuàng)度、真實(shí)性、完整性、時(shí)效性本平臺(tái)不作任何保證或承諾，涉及用藥、治療等問(wèn)題需謹(jǐn)遵醫(yī)囑！請(qǐng)讀者僅作參考，并自行核實(shí)相關(guān)內(nèi)容。如有作品內(nèi)容、知識(shí)產(chǎn)權(quán)或其它問(wèn)題，請(qǐng)發(fā)郵件至suggest@fh21.com及時(shí)聯(lián)系我們處理！</div> <div 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